JAK1 and hyper-IgE syndrome: To date, eight gain of function (GOF) JAK1 variants have been described in families with autosomal dominant autoinflammatory-related disease, including allergies and dermatitis, along with eosinophilic disorder and hyperimmunoglobulin E syndrome (HIES) (Takeichi et al, 2022; Gruber et al, 2020; Horesh et al, 2024; Del Bel et al, 2017; Fayand et al, 2023).