EV patients carry biallelic loss-of-function mutations in TMC6 encoding Transmembrane channel-like protein 6 or EV protein 1 (EVER1), TMC8 encoding Transmembrane channel-like protein 8 or EV protein 2 (EVER2), or CIB1 encoding Calcium and integrin-binding protein 1. Here, TMC8 is linked to epidermodysplasia verruciformis.