In p53-expressing hepatocellular carcinoma cells, LINC01612 promotes ATF3 expression by sponging miR-494 and activating the p53 pathway, while in p53-null cells, LINC01612 binds to YBX1 and promotes its degradation to suppress tumor progression (Liu et al., 2022). The gene discussed is YBX1; the disease is hepatocellular carcinoma.