For example, miR125b, miR-21, miR-378, and miR-652 serve as signals for maintaining the self-renewal of snail-induced stem cells, mesenchymal stem cells, and colon cancer stem cells, respectively (Deng et al., 2013; Yang et al., 2020; Yu et al., 2015); miR-34, miR-451, and let-7 families promote the differentiation of neural stem cells and cancer stem cells (Aranha et al., 2011; Bitarte et al., 2011; Büssing et al., 2008; Peng et al., 2017). Here, SNAI1 is linked to colonic neoplasm.