Parkinson’s disease (PD), multiplesystem atrophy (MSA),and dementia with Lewy bodies (DLB) are conditions categorized as‘synucleinopathies’, which exhibit hallmark intracellularaggregates of α-synuclein (αSyn). Given the prominence of these amyloid aggregates in synucleinopathies,they are hypothesized to play a role in disease,−,  and are keymarkers of pathogenesis. The gene discussed is SNCA; the disease is synucleinopathy.