PAX3 and rhabdomyosarcoma: This fusion protein consists of the N-terminal portion of human PAX7—including the paired and homeodomain DNA-binding domains—fused to the same C-terminal FOXO1 moiety used in the PAX3-FOXO1 construct, this corresponds to the PAX7-FOXO1 fusion protein associated with certain forms of alveolar rhabdomyosarcoma [36].