Infection with H5N1 (SY) and H1N1 (PR8) viruses induced RORγ and HMGCR expression in a dose- and time-dependent manner, along with an increase in the active form of nuclear SREBP2 (nSREBP2) and a decrease in the full-length SREBP2 precursor (pSREBP2) in NL20 cells, a human bronchial noncancerous epithelial cell line (Fig 1A and 1B). Here, HMGCR is linked to infection.