Several pathways and molecules have been shown to regulate Bhlhe40 expression: TCR signaling can rapidly induce Bhlhe40 expression; cytokines such as IL-1β can induce Bhlhe40 expression in T cells43; GATA3 may regulate Bhlhe40 expression in pathogenic Th17 cells of the experimental autoimmune encephalomyelitis model.44 However, we do not know what signal(s) regulate Bhlhe40 dynamics during Tfh cell differentiation. This evidence concerns the gene BHLHE40 and experimental autoimmune encephalomyelitis.