IL1B and experimental autoimmune encephalomyelitis: Several pathways and molecules have been shown to regulate Bhlhe40 expression: TCR signaling can rapidly induce Bhlhe40 expression; cytokines such as IL-1β can induce Bhlhe40 expression in T cells43; GATA3 may regulate Bhlhe40 expression in pathogenic Th17 cells of the experimental autoimmune encephalomyelitis model.44 However, we do not know what signal(s) regulate Bhlhe40 dynamics during Tfh cell differentiation.