AIF1 and Alzheimer disease: Additionally, emerging evidence indicates that microglial phagocytosis also plays a key role in clearing extracellular p‐tau, thereby preventing its spread and slowing AD progression.[59, 60, 61, 62] Our 3D surface reconstruction studies further revealed that Iba1+CD68+ microglial phagosomes not only surrounded but also highly colocalized with AT8‐positive p‐tau (Ser202 and Thr205) (Figure S10C, Supporting Information).