The 3xTg‐AD mice is widely used for studying AD, as it carries mutations in the APP, MAPT, and PSEN1 genes, allowing it to develop both Aβ plaques and neurofibrillary tangles.[42] Strikingly, VUF6002‐treated aged 3xTg‐AD mice showed substantially higher alterations in the Y‐maze test compared to aged 3xTg‐AD mice, indicating that VUF6002 treatment effectively reversed working memory deficits in these aged 3xTg‐AD mice (Figure 2I). This evidence concerns the gene PSEN1 and Alzheimer disease.