MAPT and Alzheimer disease: Key pathological features of AD include extracellular amyloid‐β (Aβ) aggregation, intracellular neurofibrillary tangles formation primarily caused by hyperphosphorylated tau (p‐tau) aggregation, reactive microgliosis, and neuroinflammation.[1, 2, 3] Genome‐wide association studies have identified over 20 genetic risk factors linked to the development of late‐onset AD.