More strikingly, representative 3D reconstruction images revealed that microglial Hrh4 deletion markedly enhanced the internalization of 6E10‐positive Aβ plaques by CD68‐positive microglial phagosome within Iba1‐positive microglia, increasing this by 123% in aged APP/PS1 mice (Figure 6C), and by 75% in aged 3xTg‐AD mice (Figure 6D). This evidence concerns the gene PSEN1 and Alzheimer disease.