POU3F1 and peripheral nerve injury: Cluster 1, comprising 28.4% of all annotated SGCs, exhibits enrichment for classical SGC markers (Figure 1C,D) as well as genes involved in the cholesterol and fatty acid biosynthetic pathways (Figure S1B, Supporting Information) previously reported to be regulated in SGCs following peripheral nerve injury.[26, 27] Cluster 2, representing 14.8% of SGCs, shows enrichment for Pou3f1 (encoding the transcription factor OCT6), which is also strongly expressed in annotated Schwann cells (Figure 1C,E).