In multivariate analysis, independent predictors of survival were age (HR 1.06, p < 0.001), LDH ≥ 240 U/L (HR 2.16, p < 0.001), β2‐microglobulin (HR 1.02, p = 0.007), hypercalcemia (HR 1.73, p = 0.003), ECOG status (HR 1.44, p < 0.001), κ FLC type (HR 0.60, p = 0.002), baseline eGFR (HR 1.04, p = 0.003), dialysis requirement (HR 1.61, p = 0.031), presence of ≥ 2 high risk cytogenetic aberrations (HR 1.65, p = 0.009), and myeloma response (HR 0.47, p < 0.001) (Table 5). This evidence concerns the gene HLA-G and hypercalcemia disease.