This study demonstrates that combined aerobic and resistance training reverses HF-induced tPVAT dysfunction by restoring brown adipocyte phenotype, reducing inflammation and oxidative stress, and reactivating the noradrenaline/β3-adrenoceptor/adiponectin/AMP-activated protein kinase/endothelial nitric oxide synthase signaling pathway. This evidence concerns the gene ADIPOQ and hydrops fetalis.