EPSTI1 and hydrops fetalis: Our previous findings demonstrated that animals with HF had a significant change in the adipocyte phenotype in tPVAT, changing a thermogenic brown adipocyte to a lipid store profile (whitening), with a reduction in gene expression of brown and beige adipose tissue markers (PRDM-16 and EPSTI-1, respectively) and an increase in the white adipose tissue marker (TCF-21), contributing to the impairment of the anticontractile function of tPVAT found in HF [11].