ECS width changes can impact interstitial fluid flow, potentially leading to impaired clearance and the accumulation of pathological proteins, as suggested by others.[66] Finally, ECS widening is often associated with neuroinflammatory responses in AD,[67] which, in turn, may exacerbate the spread of pathological proteins by promoting cellular damage and dysfunction, creating an environment conducive to the propagation of Aβ and tau pathologies. The gene discussed is MAPT; the disease is Alzheimer disease.