Interestingly, reduced insulin clearance controlled by nitric oxide46 and is associated with lower hepatic carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) levels, responsible for insulin receptor internalization, and declining human circulating CEACAM1 levels parallel the progression of insulin resistance, hyperinsulinemia, increased BMI and hepatic steatosis.47 This evidence concerns the gene INSR and hyperinsulinism.