<h4>Objective</h4>To investigate the effect of short-term intensive insulin (STII) pump therapy on serum endotrophin (ETP) levels in patients with newly diagnosed type 2 diabetes, examine the relationship between serum ETP levels and insulin resistance (IR).<h4>Subjects and methods</h4>Our study recruited 40 patients with newly diagnosed type 2 diabetes and 40 healthy controls. The gene discussed is INS; the disease is type 2 diabetes mellitus.