SOD1 and amyotrophic lateral sclerosis: In another study with superoxide-dismutase 1 (SOD1)-mutant transgenic mice, the animal model of familial ALS, a combination of intrathecal and intramuscular MSC administered to these animals exhibited an increase in motor neuron survival, maintained neuromuscular junctions in quadriceps femoris and showed a substantial reduction involved in necroptosis, apoptosis and autophagy (35).