Using the MethylMix software package, 471 MDGs were identified, and five pain-related MDGs (PSMB8/COL17A1/BICC1/CTRC/TRIP13) significantly associated with overall survival (OS) were finally selected for prognostic stratification of PC patients (HR = 3.83, p < 0.001). This evidence concerns the gene COL17A1 and pachyonychia congenita.