Using Western blot and immunohistochemistry/immunocytochemistry (IHC/ICC) analysis, we discovered that both lathyrol and paraplatin could affect the expression of cyclin proteins, which play a blocking role in the cell cycle, and also impact the expression of cell cycle regulatory proteins CDK and CKI, indirectly influencing the normal operation of the RCC cell cycle. Here, CHKA is linked to renal cell carcinoma.