CCNE1 and renal cell carcinoma: After treatment with lathyrol and paraplatin, the expression of cyclinD1, cyclinB1, cyclinE1, CDK4, CDK6, CDK2, and CDK1 in group A RCC xenografts was greater than that in groups B and Cwhereas the expression of P16, P21, and P27 in groups B and C was greater than that in group A. However, lathyrol and paraplatin had a negligible effect on the expression of cyclin A1 protein in Renca cells in vivo, and the cell cycle might be blocked in the G1 phase.