PCNA and renal cell carcinoma: Using Western blot and immunohistochemistry/immunocytochemistry (IHC/ICC) analysis, we discovered that both lathyrol and paraplatin could affect the expression of cyclin proteins, which play a blocking role in the cell cycle, and also impact the expression of cell cycle regulatory proteins CDK and CKI, indirectly influencing the normal operation of the RCC cell cycle.