Integration and analysis of the relevant data revealed that the expression of TGF-β1, Smad1, Smad2, Smad3, Smad4, and Smad9 in malignant tissues was greater than that in the model control group, whereas the expression of Smad6 was significantly higher in the model control group than in the tumor group. The gene discussed is SMAD6; the disease is neoplasm.