Since TNF-treated Slc25a13-/- mice were characterized by more prominent hyperlactatemia (Supplementary Figure S3D) and adequate NAD+ and NADH levels are crucial for sustaining glycolysis and oxidative phosphorylation, we next investigated the impact of citrin LOF on carbohydrate metabolism in TNF-induced SIRS. Here, SLC25A13 is linked to systemic inflammatory response syndrome.