KRAS and familial pancreatic carcinoma: However, it has been reported that autophagy-dependent degradation of MHC-I causes a reduction in cell surface MHC-I levels, leading to immune evasion in pancreatic cancers.25 Furthermore, aberrant localization of membrane protein Scribble to the cytoplasm has been associated with resistance to KRAS inhibitors.26 Inhibition of the molecular mechanisms behind these molecules has been shown to reverse drug-resistant cancer cells into sensitive ones.