MAPK1 and neoplasm: This result was surprising, but several papers have reported that in mouse tumor models, oncogenic Ras activity (GTP-binding) and ERK phosphorylation are significantly reduced by ablation or inhibition of the EGFR, paralleled by reduced tumorigenesis (Ardito et al., 2012; Bardeesy et al., 2005; Dlugosz et al., 1997; Kruspig et al., 2018; Larbouret et al., 2007; Moll et al., 2018; Ponsioen et al., 2021; Sibilia et al., 2000).