HTR1A and schizophrenia: Antidepressants also target post-synaptic 5-hydroxytryptamine type 3 (5-HT3) receptors and presynaptic α2-adrenergic receptors and indirectly stimulate post-synaptic 5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) receptors (de Boer, 1996), all of which are implicated in the pathophysiology of schizophrenia.