A nonexperimental study using a retrospective design and data collected between 2018 and 2021 was completed to explore whether the presence of positive anti‐ENA and anti‐dsDNA antibodies in individuals with an autoimmune disorder (anti‐ENA, N = 1495; anti‐dsDNA, N = 1261) can be predicted by their demographics and selected general laboratory test results. The gene discussed is ENAH; the disease is Autoimmunity.