Additionally, patients were tested for anti‐Sjogren's syndrome A (SSA Ro), anti‐Sjogren's syndrome B (SSB La), RNP/Sm, Polymyositis antibodies (Jo‐1), Sm, Scleroderma antibodies (Scl‐70), chromatin, centromere, histone, and RNA polymerase III within an anti‐ENA panel. The gene discussed is RNPC3; the disease is Down syndrome.