Co-immunoprecipitation analysis validated the interactions of nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1).<h4>Results</h4>HDAC3 levels were increased in the serum and kidney tissues of patients with SLE and LN, and the LN group posted the highest level. This evidence concerns the gene NFE2L2 and systemic lupus erythematosus.