HDAC3 and lobular neoplasia: Our study objective was to explore the accurate role and mechanism of HDAC3 in the RIF of LN.<h4>Methods</h4>To knock down HDAC3, Murphy Roths large (MRL)/wt and MRL/MpJ-Faslpr/J (MRL/lpr mice were injected with lentiviral short hairpin RNAs.