In addition, we generated inducible overexpression of PTEN in PTEN-deficient cell lines, including SPAC-1-L and Ishikawa (EC lines) as well as HCC1937 (breast cancer) to demonstrate that EphA2 was downregulated in cancer cells with PTEN overexpression (Fig. 6E). The gene discussed is PTEN; the disease is breast carcinoma.