Given the high frequency of genetic alterations in the PI3K signaling pathway, particularly involving PIK3CA and PTEN, in breast cancer (4), we investigated the relationship between patient survival and expression levels of PTEN and EphA2, using the Breast Invasive Carcinoma database (TCGA, provisional) from cBioPortal (40). This evidence concerns the gene PIK3CA and invasive breast carcinoma.