In tauopathies such as AD, Tau with abnormalphosphorylation mislocatesfrom MT-binding and aggregates into pathogenic forms, including solubleoligomers, insoluble fibrils, and NFTs.,,−,  Although insoluble NFTs composedof insoluble fibrils are a hallmark of tauopathies, soluble oligomers,particularly low-weight ones such as dimers and trimers, are recognizedas major contributors to tau pathologies.−, ,, Thus, it is of greatinterest to investigate tau oligomerization regarding abnormal phosphorylation,to support the development of therapeutic agents targeting tau aggregation-relateddiseases. This evidence concerns the gene MAPT and Alzheimer disease.