NLRP3 and colitis: The anti-inflammatory and the antioxidant's efficacy of TXM peptides was evaluated using the tetra peptides TXM-CB13 both in-vivo, in a dextran sulfate sodium (DSS)-induced colitis mouse model, and in vitro, in LPS-induced NLRP3 inflammasome activation in RAW264.7 macrophages (Table II) [65].