Additionally, IDO1 knockdown reduced the proliferation and invasion of PRMT3-mediated tumor cells following radiotherapy, whereas PRMT3 overexpression after IDO1 knockdown had no significant effect on cell proliferation and migration compared with cells with only IDO1 knockdown (Fig. 3E–H; Supplementary Figs. S5D–S5 and S6A). The gene discussed is IDO1; the disease is neoplasm.