TNF and neoplasm: Consistent with the results of Western blot analysis, the transcriptional activation of Ido1 and various proinflammatory factors, such as Ifnb1, Ifng, Il6, and Tnf, was verified in BMDCs and MC38 tumor cells treated with STING-NP, free drug combination (FDC), and iBINP compared with those of the negative control group (Figure 4H and Supplemental Figure 4, C and D).