Strikingly, while control animals developed T-ALL with infiltration of multiple organs but no meningeal involvement, forced CXCR3 expression drove robust meningeal infiltration, underscoring a potential role for CXCR3 in directing T-ALL cell trafficking to the meninges (Figure 3K and Supplemental Figure 3Z). Here, CXCR3 is linked to acute lymphoblastic leukemia.