Given the implication of CXCR3-CXCL10 signaling in the migration of normal T cells across the blood–CSF barrier during inflammation (43, 50, 54), we hypothesized that T-ALL cells may exploit normal T cell function and adopt proinflammatory pathways to facilitate leukemic cell migration and dissemination into the meninges. Here, CXCR3 is linked to acute lymphoblastic leukemia.