Furthermore, CXCR3 polyubiquitination was increased in T-ALL and HEK293 cells expressing USP7 CS compared to USP7 WT, underscoring the importance of the catalytic function of USP7 in maintaining CXCR3 protein levels (Figure 4J and Supplemental Figure 4B). Here, USP7 is linked to acute lymphoblastic leukemia.