Postnecropsy tissue analyses performed on terminal mice revealed a decrease in the number of T-ALL cells infiltrating the meninges but not the BM or other organs in CXCL10-KO mice compared with the control animals, which presented with high levels of T-ALL cells in the BM and extramedullary tissues (Figure 5E and Supplemental Figure 5G). This evidence concerns the gene CXCL10 and acute lymphoblastic leukemia.