While additional studies are needed to elucidate the mechanistic basis of CXCR3-mediated T-ALL cell migration and meningeal infiltration, our findings underscore CXCR3’s role in T-ALL dissemination and highlight it as a promising therapeutic target, warranting further evaluation of CXCR3-directed therapies in both preclinical and clinical settings. The gene discussed is CXCR3; the disease is acute lymphoblastic leukemia.