Knockout or pharmacological inhibition of CXCR3 in T-ALL cells (Figure 7, L–O, and Supplemental Figure 7, G–M) or CXCL10 in LeC, Per, and DuF (Figure 7, P–S, and Supplemental Figure 7, N–T) reduced the expression of VLA-4 and VCAM-1 in T-ALL and stromal cells, respectively, further supporting the role of CXCL10-CXCR3 in regulating T-ALL adhesion to meningeal stroma. This evidence concerns the gene CXCR3 and acute lymphoblastic leukemia.