CXCR3 and acute lymphoblastic leukemia: To examine the effect of CXCR3 on T-ALL progression, we performed CRISPR/Cas9–mediated knockout (KO) of CXCR3 in KOPTK1 and PER117 cell lines, which exhibited higher levels of CXCR3 expression (Supplemental Figure 2, A–C).