Given the implication of CXCR3-CXCL10 signaling in the migration of normal T cells across the blood–CSF barrier during inflammation (43, 50, 54), we hypothesized that T-ALL cells may exploit normal T cell function and adopt proinflammatory pathways to facilitate leukemic cell migration and dissemination into the meninges. This evidence concerns the gene CXCL10 and acute lymphoblastic leukemia.