Furthermore, the secretome of hMSC-Ex-4 displayed an altered protein profile, including enhanced secretion of insulin-like growth factor–binding protein 2 (IGFBP2) and apolipoprotein M (APOM), both of which are implicated in metabolic regulation and may contribute to the therapeutic modulation of type 2 diabetes mellitus [18]. This evidence concerns the gene IGFBP2 and diabetes mellitus.