Consistent with these findings, SOX2 has been implicated in Mesenchymal-to-Epithelial Transition (MET), the reverse process of EMT, as SOX2 KD in colorectal cancer cells alters the expression of key genes involved in EMT, leading to increased E-cadherin and decreased Vimentin expression [53]. The gene discussed is SOX2; the disease is colorectal cancer.