They are usually used concurrently,for example, acetylcholinesterase inhibitors like donepezil and memantineact on raising the acetylcholine level in the brain to ensure bettercells communication, haloperidol and risperidone relieve the behavioraland psychological symptoms of dementia including agitation, anxiety,wandering, aggression delusions, and hallucinations, or decrease thedepression episodes associated with AD. This evidence concerns the gene ACHE and Alzheimer disease.