TNF and Alzheimer disease: In AD, the histopathological findings of 3 articles showed that AGhad the ability to prevent and/or decrease crucial events in AD pathogenesis,including inhibiting the production of TNF-a, interleukin-1b, andcyclooxygenase-2, and the activation of microglia and astrocytes inthe hippocampal tissue, or reducing hippocampalmicrogliosis, cholinergic fiber loss, and β-amyloid deposition., Many attempts with other natural molecules have been made to obtainsimilar effects produced by AG.