GHRL and Cachexia: Peptides, in general,pose significant formulation challenges due to their enzymatic instability,poor membrane permeability, and susceptibility to rapid clearance. Only a small number of studies have exploreddelivery strategies for ghrelin, most of which are directed towardthe treatment of cachexia and are still in the early development stage.Moeller et al. formulated ghrelin into various liposomal systems toinvestigate peptide-liposome interactions and assess in vivo pharmacologicaleffects following subcutaneous administration.