ALB and cancer: It is important to rememberthat the presence of HSA on the surface of MPs ensures their cellularinternalization and, consequently, that of the ligands they contain.This is because HSA can recognize different receptors expressed onvarious cell types, including SPARC receptors that are overexpressedin cancer cells. Here, we observed thatthe MP synthesis process induces significant structural changes inHSA, with an increase in β-sheet content at the expense of α-helixcontent.