In the context of tumor invasion and metastasis, MIF may enhance tumor cell motility through multiple mechanisms—for instance, by activating Rho GTPases and promoting the polymerization of filamentous actin to remodel the cytoskeleton, or by inducing epithelial–mesenchymal transition (EMT) via modulation of the TGF-β pathway (55). The gene discussed is TGFB1; the disease is neoplasm.