Immunohistochemistry results with intestinal CDX-2 staining were as follows (Figure 4C): cancer cells CDX-2 (+), Pax-8 (-), uterine and bilateral adnexa, high-grade adenocarcinoma (originating from the female reproductive system) with extensive necrosis in the right ovary, and 0.1-cm thick cancerous residue. The gene discussed is PAX8; the disease is cancer.