ZDHHC2 and Familial prostate cancer: Our recent studies have shown that ZDHHC2 promotes sunitinib resistance in renal cell carcinoma by increasing the membrane localization of acylglycerol kinase (AGK).[35] Similarly, we demonstrated that ZDHHC2 promotes enzalutamide resistance in prostate cancer cells, and mechanistically, we discovered that ZDHHC2 inhibits ferroptosis in prostate cancer cells.