NanoSTING@Mn exerts its immune‐stimulatory effects by coactivating cGAS with Mn2+ and STING with its agonist ADU‐S100.[10] Unlike TLRs, which are largely restricted to immune cells,[66] the cGAS–STING pathway is expressed in nearly all nucleated cells, including epithelial and tumor cells.[33] In noninflamed tissues or immune‐desert tumors, this widespread expression makes the cGAS–STING pathway a more effective target for initiating localized innate immune responses. The gene discussed is CGAS; the disease is neoplasm.