Gene signatures associated with NK‐cell cytotoxicity and activation (Gzma, Prf1, Klrd1, Nkg7, and Klrk1) were markedly upregulated at high proportions of NK cells in nanoSTING@Mn combined with LLL on dLNs and Tumor, as compared to nanoSTING@Mn alone (Figure 4G, bottom). The gene discussed is PRF1; the disease is neoplasm.