WDR62 and autosomal recessive primary microcephaly: Furthermore, 4D-NTs seeded with iPSCs with a mutation in WDR62, associated with autosomal recessive primary microcephaly (MCPH), recapitulate the earlier observations obtained in 2D/3D neural cultures, thereby validating the newly developed 4D-NT platform and suggesting it represents a tool that can facilitate understanding of human neural development and disease.