To determine if the SNCA[Δ] seen in PFF treated neurons accumulate in vivo with SNCA pathology and to determine how the SNCA[Δ] compares to previously identified C-terminally truncated SNCA [14], we compared the SNCA from PFF treated neurons with the insoluble SNCA from the transgenic mouse expressing A53T mutant human SNCA (TgA53T) and human brain affected by α-synucleinopathy (Figure 4(G)). The gene discussed is SNCA; the disease is synucleinopathy.