AKT1 and neoplasm: Forinstance, BG extract has been found to suppress the growth of HT-29human colon cancer cells in a time- (24, 48, and 72 h) and dose-dependent(20, 50, and 100 mg/mL) manner, and promote apoptosis by acting onthe phosphoinositide 3-kinase/protein kinase B (Akt) signaling pathway. Similarly, black garlic extract induced apoptosisin SGC-7901 human gastric cancer cells and even reduced tumor massin a murine model, starting from the lowest tested dose of 200 mg/kg(intraperitoneally administered).