Pathway enrichment showed strong enrichment of genes related to cytokine production, TLR signaling/NF-κB activation and lipid transport (Fig. 2l), further supporting our observation that loss of MEF2C produces a hyperinflammatory phenotype with similarities to ASD-related, aging and neurodegenerative (that is, AD) microglial states (Fig. 2m). This evidence concerns the gene MEF2C and Alzheimer disease.