KEGG pathway analysis on il26-/- guts revealed activation of “cell cycle” (Fig. EV1A), with upregulation of genes such as myca (Myc proto-oncogene a), a transcription factor that promotes proliferation (Zacarías-Fluck et al, 2024); and ccnh (cyclin H), which controls cell cycle progression and promotes cancer growth (Mao et al, 2021; Patel et al, 2016; Peng et al, 2020) (Fig. 1B). Here, CCNH is linked to cancer.