Previous studies already revealed that GHR-KO pigs closely resemble the hallmarks of GH insensitivity such as endocrine disruptions, postnatal growth retardation, altered body composition, juvenile hypoglycemia, decreased insulin secretory capacity, and alterations in metabolic pathways in the liver [[11], [12], [13], [14], [15], [16]]. This evidence concerns the gene GH1 and Hypoglycemia.