MTOR and bacterial infectious disease: We also conducted pathway analysis based on theKEGG pathway collection(Figure B,B), which mainly determines the interaction betweendifferent biological pathways. Interestingly,we identified several bacterial infection-associated pathways, that were highly upregulated in EVs isolated from M. ab-infected RAW 264.7 cells compared to EVs fromuninfected RAW 264.7 cells, including the pathways regulating phagosomeand lysosome function, efferocytosis, mTOR signaling, and cellularresponse to Salmonella infection (Figure B).