WWOX and developmental and epileptic encephalopathy, 28: Germline loss‐of‐function mutations in the WWOX gene have been reported to be associated with a severe early‐onset epileptic encephalopathy called WOREE syndrome.[27] Case‐control association studies have reported that some germline WWOX variants were related to cancer susceptibility.[42] However, it is poorly understood whether and how these WWOX variants lose the function of a tumor suppressor.