WWOX and liver cancer: have demonstrated that Wwox conditional deletion in genetically‐engineered mice accelerated the formation of pancreatic cancer by enhanced macrophage infiltration and cancer stemness.[14] In liver cancer, loss of WWOX leads to metabolic reprogramming by increased HIF1α level, thereby increasing cancer cell proliferation.[15, 16] Furthermore, previous studies have demonstrated that WWOX‐deficient cells were more susceptible to genomic instability, due to their direct participation in DNA damage repair.