Previous studies have shown that cancer cells with a deficiency of DNA damage repair were sensitive to chemotherapy.[38] Indeed, we found that chemo‐drug cisplatin induced more Annexin V‐positive apoptotic cells in CAL‐62 cells stably expressed with WWOXP252A and WWOXP282A mutants, compared with CAL‐62 cells stably expressed with wild‐type WWOX (Figure 5D; Figure S7, Supporting Information). The gene discussed is WWOX; the disease is cancer.