WWOX and neoplasm: indicated that WWOX interacted with BRCA1, and the loss of WWOX expression significantly altered DSB repair pathways, from the decreased non‐homologous end joining (NHEJ) to the enhanced homology‐directed repair (HDR) and single‐strand annealing (SSA).[19] Thus, WWOX exhibits tumor suppressive activity by the inhibition of cellular proliferation and invasion, as well as the maintenance of genomic stability.