EIF2AK2 and colorectal cancer: Five pathways were predicted to be downregulated in periodontitis: IL-17 Signaling (Z-score=-2; four downregulated genes), Breast Cancer Regulation by Stathmin1 (Z-score=-1.13; seven downregulated genes), Colorectal Cancer Metastasis Signaling (Z-score=-1; one upregulated and three downregulated genes), Production of Nitric Oxide and Reactive Oxygen Species in Macrophages (Z-score=-1; four downregulated genes), and Role of PKR in Interferon Induction and Antiviral Response (Z-score=-1; one upregulated and five downregulated genes) (Figures 2B and 2C).