In the IL-17 Signaling pathway, identified as the most suppressed CP, FOS, JUN, Matrix Metallopeptidase 13 (MMP-13), and C-C Motif Chemokine Ligand 20 (CCL20) were downregulated in periodontitis tissues (Log2FC<-1.5) (Supplementary Table 1 and Table 2). This evidence concerns the gene JUN and periodontitis.