Retinal hyperpermeability, evaluated by fundus fluorescein angiography, showed increased dye leakage and loss of intracapillary fluorescein only in wild-type Lrg1+/+ STZ mice after 6 months of hyperglycemia, whereas retinal permeability in Lrg1-/- mice was unchanged at all 3 time points studied (Fig. 2, A and B). This evidence concerns the gene LRG1 and Hyperglycemia.