Developing biodegradable, biocompatibledrug delivery systems remainsa key goal of current research, and our cofunctionalized NFs showedno cytotoxicity toward healthy cells, lacking elevated MMP-9 expression.In contrast, MMP-9 pretreatment triggered drug release and led toa ∼80% reduction in cell viability after 72 h, validating theNF’s MMP-9-responsive, tumor-specific release mechanism. Here, MMP9 is linked to neoplasm.