It has been shown that FOXO1 contributes to the development of gastric and epithelial ovarian cancers (Aird and Zhang, 2015), regulates cellular metabolic reprogramming in response to intrinsic or extrinsic stress, as well as controls cancer cell apoptosis through the regulation of target genes (Salih and Brunet, 2008; Hornsveld et al., 2018). Here, FOXO1 is linked to cancer.